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BACKGROUND:Recent studies demonstrated that allergy to natural rubber latex is frequently associated with hypersensitivity to avocado fruit. The responsible cross-sensitizing allergen has not been identified.
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OBJECTIVE:The purpose of this study was to investigate the cross-reactivity of a latex major allergen, hevein, with avocado proteins. METHODS:Serum samples from 118 health care workers (HCWs) allergic to latex (HCW group) and 78 patients with spina bifida (SB) allergic to latex (SB group) were included in this study. Anti-hevein and anti-avocado IgE antibodies were measured by enzyme-linked allergosorbent assay. Cross-reactivity of hevein to avocado proteins was assessed by inhibition of the IgE binding in individual patients' sera containing IgE antibodies to both hevein and avocado. RESULTS:The prevalence of seropositive IgE antibodies to avocado was found to be strongly associated with the presence of hevein-specific IgE antibodies in subjects of both groups (P.
Responses to Frequently Asked Questions Concerning Rule 611 and Rule 610 of Regulation NMS Division of Trading and Markets: Responses to Frequently Asked Questions Concerning Rule 611 and Rule 610 of Regulation NMSApril 4, 2008 Update (last updated on June 8, 2007)Responses to these frequently asked questions (“FAQs”) were prepared by and represent the views of the staff of the Division of Trading and Markets (“Staff”). They are not rules, regulations, or statements of the Securities and Exchange Commission (“Commission”). Further, the Commission has neither approved nor disapproved of these interpretive answers.For Further Information Contact: Theodore S. Venuti, Special Counsel, at (202) 551-5658; Division of Trading and Markets, Securities and Exchange Commission, 100 F Street, NE, Washington, DC.
INTRODUCTIONOn April 6, 2005, the Commission adopted Regulation NMS, a series of initiatives designed to modernize and strengthen the national market system for equity securities. Regulation NMS was published in Securities Exchange Act Release No.
9, 2005), 70 FR 37496 (Jun. 29, 2005) (“NMS Release”).
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It includes: (1) Rule 610, which addresses access to markets; (2) Rule 611, which provides intermarket price priority for displayed and accessible quotations; (3) Rule 612, which establishes minimum pricing increments; and (4) amendments to the joint-industry plans and rules governing the dissemination of market data. This document jointly addresses Rule 611 and Rule 610 because the price priority and access issues arising under the two rules often are intertwined. On May 18, 2006 and January 24, 2007, the Commission extended the compliance dates for the Rules to a series of five dates, beginning on October 16, 2006.Rule 611, among other things, requires trading centers to establish, maintain, and enforce written policies and procedures reasonably designed to prevent “trade-throughs” – the execution of trades at prices inferior to protected quotations.
To be protected, a quotation must, among other things, be immediately and automatically accessible and be the best bid or best offer of a national securities exchange or national securities association (collectively, “self-regulatory organizations” or “SROs”). In addition, Rule 611(b) sets forth a series of exceptions that are designed to provide efficient and workable intermarket price priority. The exception that is likely to be used most frequently is for intermarket sweep orders (“ISOs”). The ISO exception enables a destination trading center to execute an ISO immediately at its limit price or better, while also requiring that additional ISOs, as necessary, be routed to execute against the full displayed size of any better-priced protected quotations.
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